BDBM30192 Pyrrolopyridine, 23

SMILES Fc1ccccc1-c1cc(ccn1)-c1cc2c(CCNC2=O)[nH]1

InChI Key InChIKey=XJJYJNMNYDNXNO-UHFFFAOYSA-N

Data  10 IC50  2 EC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 30192   

TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50:  126nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataEC50:  2.70E+3nMAssay Description:Inhibition of MK2 in LPS-stimulated human THP1 cells assessed as inhibition of Hsp27 phosphorylation pretreated 60 mins before LPS challenge measured...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataEC50:  372nMAssay Description:Inhibition of MK2 pretreated for 30 mins before fluorescein labeled substrate peptide addition measured after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50:  560nMAssay Description:Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysisChecked by AuthorMore data for this Ligand-Target Pair